hydroxycitric acid Search Results


94
MedChemExpress hydroxycitric acid
Hydroxycitric Acid, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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86
ChromaDex hydroxycitric acid calcium salt
HPLC chromatogram from G. humilis rind and pulp, and citric and <t>hydroxycitric</t> acids at 210 nm.
Hydroxycitric Acid Calcium Salt, supplied by ChromaDex, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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92
ChromaDex hydroxycitric acid hca
HPLC chromatogram from G. humilis rind and pulp, and citric and <t>hydroxycitric</t> acids at 210 nm.
Hydroxycitric Acid Hca, supplied by ChromaDex, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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89
MedChemExpress acid garcinia hombroniana pierre clusiaceae bark 13 5
HPLC chromatogram from G. humilis rind and pulp, and citric and <t>hydroxycitric</t> acids at 210 nm.
Acid Garcinia Hombroniana Pierre Clusiaceae Bark 13 5, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 89/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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90
Dawley Inc lc-ms/ms chromatogram of hydroxycitric acid
Structures of <t>hydroxycitric</t> acid, citric acid, and hydroxycitric acid lactone
Lc Ms/Ms Chromatogram Of Hydroxycitric Acid, supplied by Dawley Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Sanherb Biotech inc hydroxycitric acid (hca
Structures of <t>hydroxycitric</t> acid, citric acid, and hydroxycitric acid lactone
Hydroxycitric Acid (Hca, supplied by Sanherb Biotech inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Dawley Inc hydroxycitric acid (hca)
Structures of <t>hydroxycitric</t> acid, citric acid, and hydroxycitric acid lactone
Hydroxycitric Acid (Hca), supplied by Dawley Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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IHEAL Inc hydroxycitric acid compositions
Structures of <t>hydroxycitric</t> acid, citric acid, and hydroxycitric acid lactone
Hydroxycitric Acid Compositions, supplied by IHEAL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Bioactive Ingredients hydroxycitric acid
Structures of <t>hydroxycitric</t> acid, citric acid, and hydroxycitric acid lactone
Hydroxycitric Acid, supplied by Bioactive Ingredients, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ZenBio hydroxycitric acid calcium salt
Structures of <t>hydroxycitric</t> acid, citric acid, and hydroxycitric acid lactone
Hydroxycitric Acid Calcium Salt, supplied by ZenBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ZenBio hydroxycitric acid-2-palmitate sodium salt
Structures of <t>hydroxycitric</t> acid, citric acid, and hydroxycitric acid lactone
Hydroxycitric Acid 2 Palmitate Sodium Salt, supplied by ZenBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


HPLC chromatogram from G. humilis rind and pulp, and citric and hydroxycitric acids at 210 nm.

Journal: Nutrients

Article Title: Achacha ( Garcinia humilis ) Rind Improves Cardiovascular Function in Rats with Diet-Induced Metabolic Syndrome

doi: 10.3390/nu10101425

Figure Lengend Snippet: HPLC chromatogram from G. humilis rind and pulp, and citric and hydroxycitric acids at 210 nm.

Article Snippet: After centrifuging for 5 minutes, an aliquot of the supernatant was taken up in a HPLC vial and run against reference standards of hydroxycitric acid calcium salt (ChromaDex, Irvine, CA, USA), citric acid (Sigma-Aldrich Australia), and malic acids (Sigma-Aldrich Australia).

Techniques:

Structures of hydroxycitric acid, citric acid, and hydroxycitric acid lactone

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Structures of hydroxycitric acid, citric acid, and hydroxycitric acid lactone

Article Snippet: To the best of our knowledge the endogenous HCA levels have not previously been reported in rodents. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 2. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Species/Matrix a Endogenous HCA (%) b (Mean ± SE) Endogenous HCA concentration (ng/mL, ng/g) c (Mean ± SE) SD Rat Plasma 25.4±1.00 5.25±0.21 Male HSD Rat Plasma 29.6±1.28 6.11±0.26 PND4 Dam HSD Rat Plasma 35.1±3.77 7.25±0.78 PND4 Male HSD Rat Pup Plasma 26.4±0.93 5.44±0.19 Male B6C3F1/N Mouse Plasma 35.8±1.95 7.38±0.40 GD18 HSD Rat Fetus Homogenate 16.3±2.69 10.1±1.71 Open in a separate window a Total of 12 sample; n=6 blank matrix and n=6 blank matrix + internal standard per matrix b Expressed as a % of the LOQ, The LOQ for HCA is approximately 20 ng/mL for plasma and 60 ng/g for fetal homogenate. c Expressed as an extrapolated concentration as ng/mL and ng/g for plasma and fetal homogenate, respectively.

Techniques:

Endogenous  hydroxycitric acid  concentration (HCA) in Sprague Dawley (SD) rat, Hsd:Sprague Dawley® SD® (HSD) rat and B6C3F1/N mouse matrix blanks

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Endogenous hydroxycitric acid concentration (HCA) in Sprague Dawley (SD) rat, Hsd:Sprague Dawley® SD® (HSD) rat and B6C3F1/N mouse matrix blanks

Article Snippet: To the best of our knowledge the endogenous HCA levels have not previously been reported in rodents. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 2. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Species/Matrix a Endogenous HCA (%) b (Mean ± SE) Endogenous HCA concentration (ng/mL, ng/g) c (Mean ± SE) SD Rat Plasma 25.4±1.00 5.25±0.21 Male HSD Rat Plasma 29.6±1.28 6.11±0.26 PND4 Dam HSD Rat Plasma 35.1±3.77 7.25±0.78 PND4 Male HSD Rat Pup Plasma 26.4±0.93 5.44±0.19 Male B6C3F1/N Mouse Plasma 35.8±1.95 7.38±0.40 GD18 HSD Rat Fetus Homogenate 16.3±2.69 10.1±1.71 Open in a separate window a Total of 12 sample; n=6 blank matrix and n=6 blank matrix + internal standard per matrix b Expressed as a % of the LOQ, The LOQ for HCA is approximately 20 ng/mL for plasma and 60 ng/g for fetal homogenate. c Expressed as an extrapolated concentration as ng/mL and ng/g for plasma and fetal homogenate, respectively.

Techniques: Concentration Assay, High Content Screening, Clinical Proteomics

Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale

Article Snippet: To the best of our knowledge the endogenous HCA levels have not previously been reported in rodents. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 2. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Species/Matrix a Endogenous HCA (%) b (Mean ± SE) Endogenous HCA concentration (ng/mL, ng/g) c (Mean ± SE) SD Rat Plasma 25.4±1.00 5.25±0.21 Male HSD Rat Plasma 29.6±1.28 6.11±0.26 PND4 Dam HSD Rat Plasma 35.1±3.77 7.25±0.78 PND4 Male HSD Rat Pup Plasma 26.4±0.93 5.44±0.19 Male B6C3F1/N Mouse Plasma 35.8±1.95 7.38±0.40 GD18 HSD Rat Fetus Homogenate 16.3±2.69 10.1±1.71 Open in a separate window a Total of 12 sample; n=6 blank matrix and n=6 blank matrix + internal standard per matrix b Expressed as a % of the LOQ, The LOQ for HCA is approximately 20 ng/mL for plasma and 60 ng/g for fetal homogenate. c Expressed as an extrapolated concentration as ng/mL and ng/g for plasma and fetal homogenate, respectively.

Techniques: Liquid Chromatography with Mass Spectroscopy, Clinical Proteomics

Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale

Article Snippet: To the best of our knowledge the endogenous HCA levels have not previously been reported in rodents. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 2. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Species/Matrix a Endogenous HCA (%) b (Mean ± SE) Endogenous HCA concentration (ng/mL, ng/g) c (Mean ± SE) SD Rat Plasma 25.4±1.00 5.25±0.21 Male HSD Rat Plasma 29.6±1.28 6.11±0.26 PND4 Dam HSD Rat Plasma 35.1±3.77 7.25±0.78 PND4 Male HSD Rat Pup Plasma 26.4±0.93 5.44±0.19 Male B6C3F1/N Mouse Plasma 35.8±1.95 7.38±0.40 GD18 HSD Rat Fetus Homogenate 16.3±2.69 10.1±1.71 Open in a separate window a Total of 12 sample; n=6 blank matrix and n=6 blank matrix + internal standard per matrix b Expressed as a % of the LOQ, The LOQ for HCA is approximately 20 ng/mL for plasma and 60 ng/g for fetal homogenate. c Expressed as an extrapolated concentration as ng/mL and ng/g for plasma and fetal homogenate, respectively.

Techniques: Liquid Chromatography with Mass Spectroscopy

Method validation data for  hydroxycitric acid  (HCA) in male Sprague Dawley (SD) rat plasma

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Method validation data for hydroxycitric acid (HCA) in male Sprague Dawley (SD) rat plasma

Article Snippet: To the best of our knowledge the endogenous HCA levels have not previously been reported in rodents. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 2. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Species/Matrix a Endogenous HCA (%) b (Mean ± SE) Endogenous HCA concentration (ng/mL, ng/g) c (Mean ± SE) SD Rat Plasma 25.4±1.00 5.25±0.21 Male HSD Rat Plasma 29.6±1.28 6.11±0.26 PND4 Dam HSD Rat Plasma 35.1±3.77 7.25±0.78 PND4 Male HSD Rat Pup Plasma 26.4±0.93 5.44±0.19 Male B6C3F1/N Mouse Plasma 35.8±1.95 7.38±0.40 GD18 HSD Rat Fetus Homogenate 16.3±2.69 10.1±1.71 Open in a separate window a Total of 12 sample; n=6 blank matrix and n=6 blank matrix + internal standard per matrix b Expressed as a % of the LOQ, The LOQ for HCA is approximately 20 ng/mL for plasma and 60 ng/g for fetal homogenate. c Expressed as an extrapolated concentration as ng/mL and ng/g for plasma and fetal homogenate, respectively.

Techniques: Biomarker Discovery, Concentration Assay

Secondary matrix evaluation for  hydroxycitric acid  (HCA) in Hsd:Sprague Dawley® SD® (HSD) rat plasma, male B6C3F1/N mouse plasma and GD18 HSD rat fetal homogenate

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Secondary matrix evaluation for hydroxycitric acid (HCA) in Hsd:Sprague Dawley® SD® (HSD) rat plasma, male B6C3F1/N mouse plasma and GD18 HSD rat fetal homogenate

Article Snippet: To the best of our knowledge the endogenous HCA levels have not previously been reported in rodents. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 2. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Species/Matrix a Endogenous HCA (%) b (Mean ± SE) Endogenous HCA concentration (ng/mL, ng/g) c (Mean ± SE) SD Rat Plasma 25.4±1.00 5.25±0.21 Male HSD Rat Plasma 29.6±1.28 6.11±0.26 PND4 Dam HSD Rat Plasma 35.1±3.77 7.25±0.78 PND4 Male HSD Rat Pup Plasma 26.4±0.93 5.44±0.19 Male B6C3F1/N Mouse Plasma 35.8±1.95 7.38±0.40 GD18 HSD Rat Fetus Homogenate 16.3±2.69 10.1±1.71 Open in a separate window a Total of 12 sample; n=6 blank matrix and n=6 blank matrix + internal standard per matrix b Expressed as a % of the LOQ, The LOQ for HCA is approximately 20 ng/mL for plasma and 60 ng/g for fetal homogenate. c Expressed as an extrapolated concentration as ng/mL and ng/g for plasma and fetal homogenate, respectively.

Techniques: Clinical Proteomics

Partial validation of  hydroxycitric acid  (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Partial validation of hydroxycitric acid (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Article Snippet: To the best of our knowledge the endogenous HCA levels have not previously been reported in rodents. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 2. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Species/Matrix a Endogenous HCA (%) b (Mean ± SE) Endogenous HCA concentration (ng/mL, ng/g) c (Mean ± SE) SD Rat Plasma 25.4±1.00 5.25±0.21 Male HSD Rat Plasma 29.6±1.28 6.11±0.26 PND4 Dam HSD Rat Plasma 35.1±3.77 7.25±0.78 PND4 Male HSD Rat Pup Plasma 26.4±0.93 5.44±0.19 Male B6C3F1/N Mouse Plasma 35.8±1.95 7.38±0.40 GD18 HSD Rat Fetus Homogenate 16.3±2.69 10.1±1.71 Open in a separate window a Total of 12 sample; n=6 blank matrix and n=6 blank matrix + internal standard per matrix b Expressed as a % of the LOQ, The LOQ for HCA is approximately 20 ng/mL for plasma and 60 ng/g for fetal homogenate. c Expressed as an extrapolated concentration as ng/mL and ng/g for plasma and fetal homogenate, respectively.

Techniques: Biomarker Discovery, Concentration Assay

Stability data for  hydroxycitric acid  (HCA) in male Sprague (SD) rat plasma, male Hsd:Sprague Dawley® SD® (HSD) rat plasma, GD18 HSD fetal homogenate, and in solution (1% formic acid/ASTM type 1 water)

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Stability data for hydroxycitric acid (HCA) in male Sprague (SD) rat plasma, male Hsd:Sprague Dawley® SD® (HSD) rat plasma, GD18 HSD fetal homogenate, and in solution (1% formic acid/ASTM type 1 water)

Article Snippet: To the best of our knowledge the endogenous HCA levels have not previously been reported in rodents. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 2. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3. caption a7 Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Species/Matrix a Endogenous HCA (%) b (Mean ± SE) Endogenous HCA concentration (ng/mL, ng/g) c (Mean ± SE) SD Rat Plasma 25.4±1.00 5.25±0.21 Male HSD Rat Plasma 29.6±1.28 6.11±0.26 PND4 Dam HSD Rat Plasma 35.1±3.77 7.25±0.78 PND4 Male HSD Rat Pup Plasma 26.4±0.93 5.44±0.19 Male B6C3F1/N Mouse Plasma 35.8±1.95 7.38±0.40 GD18 HSD Rat Fetus Homogenate 16.3±2.69 10.1±1.71 Open in a separate window a Total of 12 sample; n=6 blank matrix and n=6 blank matrix + internal standard per matrix b Expressed as a % of the LOQ, The LOQ for HCA is approximately 20 ng/mL for plasma and 60 ng/g for fetal homogenate. c Expressed as an extrapolated concentration as ng/mL and ng/g for plasma and fetal homogenate, respectively.

Techniques: Clinical Proteomics

Structures of hydroxycitric acid, citric acid, and hydroxycitric acid lactone

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Structures of hydroxycitric acid, citric acid, and hydroxycitric acid lactone

Article Snippet: Partial validation of hydroxycitric acid (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Techniques:

Endogenous  hydroxycitric acid  concentration  (HCA)  in Sprague Dawley (SD) rat, Hsd:Sprague Dawley® SD® (HSD) rat and B6C3F1/N mouse matrix blanks

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Endogenous hydroxycitric acid concentration (HCA) in Sprague Dawley (SD) rat, Hsd:Sprague Dawley® SD® (HSD) rat and B6C3F1/N mouse matrix blanks

Article Snippet: Partial validation of hydroxycitric acid (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Techniques: Concentration Assay, High Content Screening, Clinical Proteomics

Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Representative LC-MS/MS chromatogram of hydroxycitric acid for blank Sprague Dawley (SD) plasma with and without internal standard (IS), low and high hydroxycitric acid in SD rat plasma; A1: Full scale, A2: Reduced scale

Article Snippet: Partial validation of hydroxycitric acid (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Techniques: Liquid Chromatography with Mass Spectroscopy, Clinical Proteomics

Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Representative LC-MS/MS chromatogram of hydroxycitric acid for HSD:Sprague Dawley® SD® (HSD) rat fetal homogenate with and without internal standard (IS), low and high hydroxycitric acid in HSD in fetus; A1: Full scale, A2: Reduced scale

Article Snippet: Partial validation of hydroxycitric acid (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Techniques: Liquid Chromatography with Mass Spectroscopy

Method validation data for  hydroxycitric acid (HCA)  in male Sprague Dawley (SD) rat plasma

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Method validation data for hydroxycitric acid (HCA) in male Sprague Dawley (SD) rat plasma

Article Snippet: Partial validation of hydroxycitric acid (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Techniques: Biomarker Discovery, Concentration Assay

Secondary matrix evaluation for  hydroxycitric acid (HCA)  in Hsd:Sprague Dawley® SD® (HSD) rat plasma, male B6C3F1/N mouse plasma and GD18 HSD rat fetal homogenate

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Secondary matrix evaluation for hydroxycitric acid (HCA) in Hsd:Sprague Dawley® SD® (HSD) rat plasma, male B6C3F1/N mouse plasma and GD18 HSD rat fetal homogenate

Article Snippet: Partial validation of hydroxycitric acid (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Techniques: Clinical Proteomics

Partial validation of  hydroxycitric acid (HCA)  in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Partial validation of hydroxycitric acid (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Article Snippet: Partial validation of hydroxycitric acid (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Techniques: Biomarker Discovery, Concentration Assay

Stability data for  hydroxycitric acid (HCA)  in male Sprague (SD) rat plasma, male Hsd:Sprague Dawley® SD® (HSD) rat plasma, GD18 HSD fetal homogenate, and in solution (1% formic acid/ASTM type 1 water)

Journal: Analytical letters

Article Title: Development and Validation of an Analytical Method to Quantitate Hydroxycitric Acid, the Key Constituent in Garcinia cambogia Extract, in Rodent Plasma and Fetus

doi: 10.1080/00032719.2021.2005618

Figure Lengend Snippet: Stability data for hydroxycitric acid (HCA) in male Sprague (SD) rat plasma, male Hsd:Sprague Dawley® SD® (HSD) rat plasma, GD18 HSD fetal homogenate, and in solution (1% formic acid/ASTM type 1 water)

Article Snippet: Partial validation of hydroxycitric acid (HCA) in GD18 Hsd:Sprague Dawley® SD® rat fetal homogenate

Techniques: Clinical Proteomics